Separation of germline cells from somatic lineages is one of the earliest decisions of
embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors …

Abstract RING finger protein 8 (RNF8) is an E3 ligase that is pivotal for DNA repair.
However, the role of RNF8 in ulcerative colitis (UC) remains unclear. The aim of this study is …

Aims RING1 and YY1-binding protein (RYBP) is an epigenetic regulator and plays crucial
roles in embryonic development. The anti-tumor effect of RYBP has been reported in several …

Over the last decades significant advances have been made in our understanding of the
molecular mechanisms controlling organismal development. Among these mechanisms the …

RYBP (Ring1 and YY1 binding protein), an essential component of the Polycomb repressive
complex 1 (PRC1), plays pivotal roles in development and diseases. However, the roles of …

Ring1 and YY1 Binding Protein (RYBP) is a member of the non-canonical polycomb
repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a …

Ubiquitination is an important post-translational modification process that regulates many
cellular processes. Proteins can be modified at single or multiple lysine residues by a single …

恶性肿瘤是威胁中国人群健康的重要公共卫生问题. 为加强癌症防治, 保障全民健康,
国务院在发布的《 健康中国行动(2019—2030 年)》 中指出要积极预防癌症, 推进早筛查, 早诊断 …

Spermatogenesis is a complex cellular-differentiation process that relies on the precise
regulation of gene expression in spermatogonia, meiotic, and postmeiotic germ cells. The …

ABSTRACT Ring1 and Yin Yang 1-Binding Protein (RYBP) is a member of non-canonical
polycomb repressive complex 1 to mediate monoubiquitination of histone H2A at lysine 119 …