The Polycomb system is made of an evolutionary ancient group of proteins, present
throughout plants and animals. Known initially from developmental studies with the fly …

Discussion Using targeted NGS, we identified a well-known germline monoallelic MUTYH
mutation (p. G382D) in a 44-year-old woman who was diagnosed with concurrent fvPTC and …

DNA double strand breaks (DSBs) are the most deleterious kind of DNA damage and
threaten genomic integrity. Therefore, DSBs need to be repaired to avoid chromosomal …

Résumé L'intégrité de l'ADN génomique humain est maintenue par des systèmes de
réparation de l'ADN qui protègent les cellules des dommages causés par des agents …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurological disease and is
the primary focus of this thesis. ALS onset typically occurs between age 50 and 65 (O'Toole …

2 result in the elimination of extracellular pathogens and toxins through the interaction with
highly specific antibodies. The effector function of any immunoglobulin will de determine by …

Infolge endogener und exogener Einflüsse kommt es jeden Tag zu Schäden an der DNA,
dem Träger der gesamten genetischen Information. Der DNA-Doppelstrangbruch (DSB) gilt …