Background Studies associating coagulopathic changes with burn injury have relied on
limited tests such as partial thromboplastin time (PTT) and international normalized ratio …

Objectives Bromelain-based enzymatic debridement has emerged as a valuable option to
the standard surgical intervention for debridement in burn injuries. Adverse effects on …

Background The presence of acute coagulopathy and its effect on prognosis in burn patients
are unclear. No studies are extant verifying early coagulopathy before fluid administration in …

Background Previous studies have suggested that antithrombin may be beneficial for
treating coagulopathy in patients with severe burns. However, robust evidence for this idea …

Objectives Current evidence on how the use of bromelain-based enzymatic debridement
techniques (NexoBrid™) affect patient coagulation is limited. A single patient case report [1] …

Background Blood transfusions are essential to treating anaemia of burn injuries. It has
recently been observed that patients with non-major burns< 20% TBSA may also develop …

Background Pulmonary coagulopathy is a hallmark of lung injury following inhalation
trauma. Locally applied heparin attenuates lung injury in animal models of smoke inhalation …

BACKGROUND Smoke inhalation and burn injury remain a major source of morbidity and
mortality. There is known dysregulation of hemostasis in burn patients, but either …

Background During the emergent (ebb) phase (first 72 hours), the adult person with a severe
burn experiences loss of body heat, decreased metabolism, and poor tissue perfusion …

Background Navigating the complexities of a severe burn injury is a challenging endeavour
where the natural course of some patients can be difficult to predict. Straddling both the …