The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Early detection and monitoring are critical to the diagnosis and management of glaucoma, a
progressive optic neuropathy that causes irreversible blindness. Optical coherence …

Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Primary Open-Angle Glaucoma | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Para-inflammation is a tissue adaptive response to noxious stress or malfunction and has
characteristics that are intermediate between basal and inflammatory states (Medzhitov …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Objective To determine the association between diabetes mellitus (DM) and primary open-
angle glaucoma (POAG). Methods This is a systematic review and meta-analysis of case …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …