One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

Background Neurological diseases seriously affect human health, which are arousing wider
attention, and it is a great challenge to discover neuroprotective drugs with minimal side …

Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation
resulting from various factors. Crohn's disease (CD) and ulcerative colitis (UC) have been …

Macrophages, an important component of the innate immune response, are a key regulator
of intestinal microenvironment homeostasis. These cells essentially contribute to chronic …

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely
studied inflammasome and has become a hot topic of recent research. As a macromolecular …

Pyroptosis mediated by nucleotide-binding oligomerization domain (NOD)-like receptor 3
(NLRP3) inflammasome is implicated in cerebral ischemia/reperfusion (I/R) injury …

Ethnopharmacological relevance Ginseng is an ethnopharmacological herbal plant in Asian
countries, particularly in Korea, China, and Japan. Ginseng saponins, including …

Obesity-related non-alcoholic fatty liver disease (NAFLD) is connected with mitochondrial
stress and hepatocyte apoptosis. Parkin-related mitophagy sustains mitochondrial …

Background Previous studies reported that URB597 (URB) had therapeutic potential for
treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that
causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper …