The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Prolonged intermittent renal replacement therapy (PIRRT) is gaining popularity as a renal
replacement modality in intensive care units, but there is a relative lack of guidance …

The optimal dosing regimen for meropenem in critically ill patients undergoing continuous
renal replacement therapy (CRRT) remains undefined due to small studied sample sizes …

Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic …

Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients
undergoing kidney replacement therapy; however, little is known about antimicrobial …

Patients with Chronic Kidney Disease get Intermittent Haemodialysis (IHD) 3 or 4 times a
week. This provides good elimination of the waste products of metabolism. There are well …

Background Use of continuous renal replacement therapy in children receiving anti-infective
drugs may lead to inappropriate concentrations with risks related to treatment failure, toxicity …

Background: The most effective dosing strategy of meropenem for patients undergoing
continuous renal replacement therapy (CRRT) remains uncertain. This study aimed to …