Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of
ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence …

Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …

This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …

In the designed compounds, a new linker was inserted in the form of fragments with verified
VEGFR‐2 inhibitory potential, including an α, β‐unsaturated ketonic fragment, pyrazole, and …

Colorectal cancer (CRC) is a common tumor that harms human health with a high
recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low …

Colorectal cancer (CRC) is the third most common malignant tumor in the world. CRC has
high morbidity and mortality rates and it is a serious threat to human health. Ferroptosis is a …

The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …

Triple-negative breast cancer (TNBC) remains a significant clinical challenge because of its
high vascularity and metastatic and recurrent rates. Tumor angiogenesis is considered an …