Radiotherapy in leptomeningeal disease: a systematic review of randomized and non-randomized trials

SM Buszek, C Chung - Frontiers in oncology, 2019 - frontiersin.org
Background: Leptomeningeal disease (LMD), also known as neoplastic meningitis,
leptomeningeal carcinomatosis, or carcinomatous meningitis, is a rare cancer complication …

Leptomeningeal metastases of the spine: a systematic review

P Palmisciano, NS Sagoo, AF Kharbat… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Leptomeningeal metastases (LMs) of the spine have complex
management. We reviewed the literature on spine LMs. Materials and Methods: PubMed …

Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases

TK Nguyen, A Sahgal, J Detsky, EG Atenafu… - Neuro …, 2020 - academic.oup.com
Background The objective was to evaluate the risk and predictors of developing
leptomeningeal disease (LMD) in patients with brain metastases treated with 5-fraction …

Leptomeningeal carcinomatosis: molecular landscape, current management, and emerging therapies

HP Bhambhvani, AJ Rodrigues… - Neurosurgery …, 2020 - neurosurgery.theclinics.com
Leptomeningeal carcinomatosis (LMC), also known as leptomeningeal metastasis or
leptomeningeal disease, is the metastatic spread of cancer to the pia mater, arachnoid, and …

[HTML][HTML] Leptomeningeal carcinomatosis and breast cancer: a systematic review of current evidence on diagnosis, treatment and prognosis

L Mollica, C Leli, S Puglisi, S Sardi, F Sottotetti - Drugs in Context, 2021 - ncbi.nlm.nih.gov
Leptomeningeal carcinomatosis (LC) is a rare but challenging manifestation of advanced
breast cancer with a severe impact on morbidity and mortality. We performed a systematic …

Challenges and advances in diagnosis and treatment of leptomeningeal disease (LMD)

SD Ferguson, EI Fomchenko, RA Guerrieri… - Frontiers in …, 2022 - frontiersin.org
Leptomeningeal disease (LMD) is a devastating category of CNS metastasis with a very
poor prognosis and limited treatment options. With maximal aggressive therapy, survival …

Palliative radiotherapy for leptomeningeal carcinomatosis–analysis of outcome, prognostic factors, and symptom response

RA El Shafie, K Böhm, D Weber, K Lang… - Frontiers in …, 2019 - frontiersin.org
Introduction: The purpose of this article is to report our institution's 10-year experience on
palliative radiotherapy for the treatment of leptomeningeal carcinomatosis (LC), assessing …

Proteomic analysis of inhibitor of apoptosis protein‑like protein‑2 on breast cancer cell proliferation

S Xiang, L Zhu, Z Zhang, S Wang… - Molecular …, 2022 - spandidos-publications.com
Although inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) is considered to be a novel
enhancer of breast cancer proliferation, its underlying mechanism of action remains …

The role of immune checkpoint inhibitors in leptomeningeal disease: a systematic review

P Palmisciano, AS Haider, CD Nwagwu… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: Leptomeningeal disease (LMD) is a debilitating complication of advanced
malignancies. Immune-checkpoint inhibitors (ICIs) may alter disease course. We analyzed …

A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2 …

A Puszkiel, G Bousquet, F Stanke-Labesque… - Pharmaceutical …, 2023 - Springer
Background Dosing regimens of trastuzumab administered by intracerebroventricular (icv)
route to patients with HER2-positive brain localizations remain empirical. The objectives of …