Regulatory T cells (Tregs) are responsible for the maintenance of peripheral tolerance.
Animal studies have shown that administration of Tregs can prevent type 1 diabetes (DM1) …

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by
pulmonary vascular remodeling, perivascular inflammation, and right heart failure …

Autoantibodies induce various autoimmune diseases, including systemic lupus
erythematosus (SLE). We previously described that CD4+ CD25− LAG3+ regulatory T cells …

Systemic lupus erythematosus (SLE) is mediated by a chronic and dysregulated
inflammatory response. Interleukin (IL)-17, a proinflammatory cytokine, and T helper (Th) 17 …

Tissue-and organism-level biological processes often involve coordinated action of multiple
distinct cell types. Current computational methods for the analysis of single-cell RNA …

Recent reports have shown the importance of IFN-γ and T-bet+ B cells in the pathology of
SLE, suggesting the involvement of IFN-γ-producing T-bet+ CD4+ cells, ie, Th1 cells. This …

Objective Emerging evidence supports a crucial role of myeloid‐derived suppressor cells
(MDSCs) in the regulation of autoimmune diseases. However, their role in systemic lupus …

The available clinical as well as experimental studies implicate participation of T regulatory
(Treg) subsets in the pathogenesis and course of systemic lupus erythematosus (SLE) …

Methods: Twenty-five patients with active mild-to-moderate UC were enrolled in an open-
label trial. Patients were randomized to receive 2 or 8 mg of OPRX-106 administered orally …

Objective: Regulatory T cells (Tregs) are critical immune modulators to maintain immune
homeostasis and limit pulmonary hypertension (PH). This study was aimed to identify Treg …