Matrix metalloproteinases (MMPs) are zinc-dependent metalloproteinases that play
important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes …

Abstract Development of disease-modifying therapies against Alzheimer's disease (AD)
requires biomarkers reflecting the diverse pathological pathways specific for AD. We …

Autosomal dominant Alzheimer's disease (ADAD) offers a unique opportunity to study
pathophysiological changes in a relatively young population with few comorbidities. A …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at
opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it …

Identifying circulating proteins associated with cognitive function may point to biomarkers
and molecular process of cognitive impairment. Few studies have investigated the …

Dysregulation of the immune system and dietary patterns that increase inflammation can
increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional …

Cerebrospinal fluid (CSF) soluble triggering receptor expressed on myeloid cells-2
(sTREM2) is an emerging biomarker of neuroinflammation in Alzheimer's disease (AD). Yet …

(1) Background: Despite the existence of well-established, CSF-based biomarkers such as
amyloid-β and phosphorylated-tau, the pathways involved in the pathophysiology of …

Background and Objectives Neuroinflammation contributes to Parkinson disease (PD)
pathology, and inflammatory biomarkers may aid in PD diagnosis. Proximity extension assay …

Background Neuroinflammatory processes have been suggested to play a role in the
pathophysiology of neurodegenerative diseases and post-hemorrhagic hydrocephalus, but …