Trastuzumab (Trz) is a targeted anticancer drug for human epidermal growth factor receptor
2 (HER2)-positive tumors, as Trz-induced cardiotoxicity (TIC) is commonly observed in Trz …

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, affect a wide variety of
the population and pose significant challenges with progressive and irreversible neural cell …

Ropinirole is a non-ergolinic dopamine agonist used to manage Parkinson's disease and it
is characterized by poor oral bioavailability. This study aimed to design and develop …

Rivastigmine hydrogen tartrate (RIV-HT) is given orally for Alzheimer's disease. However,
oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated …

Cellulose acetate phthalate (CAP)/polyvinyl alcohol (PVA)/polyurethane (PU) nanofibers
were synthesized by simple and coaxial electrospinning (ES) processes. Doxorubicin (DOX) …

Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties
ascribed to its ability to bind free radicals and inactivate them. However, the low solubility of …

The intranasal (IN) route of administration is important for topical drugs and drugs intended
to act systemically. More recently, direct nose-to-brain input was considered to bypass the …

Intranasal delivery is a non-invasive mode of administration, gaining popularity due to its
potential for targeted delivery to the brain. The anatomic connection of the nasal cavity with …

Krabbe disease (KD) is a rare demyelinating disorder characterized by demyelination
caused by mutations in the GALC gene, resulting in toxic accumulation of psychosine …