Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

Background Concern exists that patients born with oesophageal atresia (OA) may be at high
risk for Barrett's oesophagus (BO), a known malignant precursor to the development of …

Objective To evaluate gastrointestinal (GI) risk factors for bronchiectasis in children. We
hypothesized that upper GI tract dysmotility would be associated with increased risk of …

Background: Functional luminal imaging probe (FLIP) measures pressure–geometry
relationships of digestive luminal space. When used in esophageal disorders, it provides …

Esophageal squamous cell carcinoma (ESCC) accounts for the large majority of esophageal
cancer cases worldwide. In this review, we examine the potential role of non-acidic fluid …

Objectives: After surgical repair, up to 70% of esophageal atresia (EA) patients suffer from
gastroesophageal reflux disease (GERD). The ESPGHAN/NASPGHAN guidelines on …

Objective To analyze the findings of both multichannel intraluminal impedance with pH (MII-
pH) and endoscopy/histopathology in children with esophageal atresia at age 1 year …

Background Esophagitis is prevalent in patients with esophageal dysmotility despite acid
suppression, likely related to poor esophageal clearance. Esophageal atresia (EA) is a …

Swallowing and feeding disorders are a major concern for children with oesophageal
atresia (OA) after primary or staged OA repair. Primary OA repair is associated with higher …

Children with esophageal atresia (EA) may require enteral tube feedings in infancy and a
subset experience ongoing feeding difficulties and enteral tube dependence. Predictors of …