Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of
epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and …

Introduction The PAGANINI study evaluated the efficacy and safety of the selective P2X3
antagonist eliapixant in patients with refractory chronic cough (RCC). Methods PAGANINI …

Background P2X3 receptor antagonists seem to have a promising potential for treating
patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled …

Abstract Background and Objective There is no licensed treatment for refractory chronic
cough; off-label therapies have limited efficacy and can produce adverse effects. Excessive …

Objective Adenosine triphosphate (ATP) is an essential nucleotide that is normally present
in both intracellular and extracellular compartments. Extracellular ATP (eATP) has a pivotal …

Background Effective, well-tolerated novel treatments for overactive bladder (OAB) are
lacking. The P2X3 receptor antagonist eliapixant demonstrated potential to reduce OAB …

Chronic cough is the most common complaint in respiratory clinics. Most of them have
identifiable causes and some may respond to common disease-modifying therapies …

Pelvic pain in women with endometriosis is attributed to neuroinflammation and afferent
nociceptor nerves in ectopic and eutopic endometrium. The hypothesis that uterine …

Artificial intelligence (AI) has been recognized as a powerful technique that can accelerate
drug discovery during the hit compound identification step. However, most simple deep …