Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …

Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …

Methicillin-resistant Staphylococcus aureus (MRSA), as a classic reason for genuine skin
and flimsy tissues diseases, is a worldwide general wellbeing risk and has already …

The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …

Tetrazole, a bioisostere of the carboxylic acid group, can replace the carboxyl group in drugs
to increase the lipophilicity, bioavailability and reduce side effects. Tetrazole derivatives …

A novel class of 7-thiazoxime quinolones was developed as potential antimicrobial agents
for the sake of bypassing resistance of quinolones. Biological assays revealed that some …

The incidence of invasive bacterial infections has increased remarkably over the past two
decades, which was mainly attributed to the increasing emergence of drug-resistant bacteria …

ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

Available therapeutic strategies are urgently needed to conquer multidrug resistance of
MRSA. A visible effort was guided towards the advancement of novel antibacterial …