Infective endocarditis is a relatively rare, but deadly cause of sepsis, with an overall mortality
ranging from 20 to 25% in most series. Although the classic clinical classification into …

Introduction Daptomycin is a bactericidal lipopeptide antibiotic approved for the treatment of
systemic infections (ie skin and soft tissue infections, bloodstream infections, infective …

Background: This meta-analysis aims to evaluate the effectiveness of combination therapy
for treating MSSA bacteremia. Methods: We searched Ovid MEDLINE, EMBASE, Cochrane …

Today, Enterococcus faecalis is one of the main causes of infective endocarditis in the world,
generally affecting an elderly and fragile population, with a high mortality rate. Enterococci …

Background: Infective endocarditis (IE) is still a severe disease with elevated morbidity and
mortality. Nevertheless, the last European guidelines (GL) date back to 2015, and a recent …

Introduction Methicillin-resistant and-susceptible Staphylococcus aureus (MRSA/MSSA)
infections are a major global health-care problem. Bacteremia with S. aureus exhibits high …

The overall low-quality evidence concerning the clinical benefits of different antibiotic
regimens for the treatment of infective endocarditis (IE), which has made it difficult to strongly …

MECHANISM OF ACTION—Daptomycin, a cyclic lipopeptide, is a large anionic molecule;
the primary mechanism of action is calcium-dependent depolarization of the gram-positive …

Infective endocarditis (EI) produced by enterococci ranks third among infectious endocarditis
and is a severe infection with usually subacute onset, often complicated with valvular …

Infective endocarditis is a relatively rare, but deadly infection, with an overall mortality of
around 20% in most series. Clinical manifestations have evolved in response to significant …