Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …

The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the
amygdala for processing affective responses. However, it is unclear whether the LPBN …

The opioid epidemic has led to a serious examination of the use of opioids for the treatment
of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the …

Cognitive and social capacities require postnatal experience, yet the pathways by which
experience guides development are unknown. Here we show that the normal development …

Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …