The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region
known to orchestrate diverse functions including sleep, reward processing, food intake …

Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

The lateral hypothalamic area (LHA) lies at the intersection of multiple neural and humoral
systems and orchestrates fundamental aspects of behavior. Two neuronal cell types found in …

Excitatory inputs drive burst firing of locus coeruleus (LC) noradrenaline (NA) neurons in
response to a variety of stimuli. Though a small number of glutamatergic LC afferents have …

Highlights•Hypocretin modulates neural transmission in stress-related and reward-related
brain areas.•Interactions between hypocretin and CRF can produce negative affective …

Lateral hypothalamic area (LHA) orexin neurons modulate reward-based feeding by
activating ventral tegmental area (VTA) dopamine (DA) neurons. We hypothesize that …

Exercise represents the most important integrative therapy in metabolic, immunologic and
chronic diseases; it represents a valid strategy in the non-pharmacological intervention of …