[HTML][HTML] Role of epithelial sodium channel-related inflammation in human diseases
Y Chen, X Yu, Z Yan, S Zhang, J Zhang… - Frontiers in …, 2023 - frontiersin.org
The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …
SLC26A9 in airways and intestine: secretion or absorption?
K Kunzelmann, R Centeio, J Ousingsawat, K Talbi… - Channels, 2023 - Taylor & Francis
ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …
transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the …
Ambroxol-enhanced ciliary beating via voltage-gated Ca2+ channels in mouse airway ciliated cells
D Saito, C Suzuki, S Tanaka, S Hosogi… - European Journal of …, 2023 - Elsevier
Ambroxol (ABX) facilitates the mucociliary clearance (MC) by enhancing ciliary beating in
airways. In this study, we focused on airway ciliary beating enhanced by ABX. However, little …
airways. In this study, we focused on airway ciliary beating enhanced by ABX. However, little …
Enhancement of airway ciliary beating mediated via voltage-gated Ca2+ channels/α7-nicotinic receptors in mice
D Saitoh, K Kawaguchi, S Asano, T Inui… - … -European Journal of …, 2022 - Springer
Acetylcholine (ACh), which activates muscarinic ACh receptors (mAChRs) and nicotinic ACh
receptors (nAChRs), enhances airway ciliary beating by increasing the intracellular Ca2+ …
receptors (nAChRs), enhances airway ciliary beating by increasing the intracellular Ca2+ …
[HTML][HTML] Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
M Zajac, A Lepissier, E Dréano, B Chevalier… - Frontiers in …, 2023 - frontiersin.org
Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane
Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate …
Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate …
[HTML][HTML] Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl−]i …
T Nakahari, C Suzuki, K Kawaguchi, S Hosogi… - International Journal of …, 2023 - mdpi.com
Ambroxol (ABX), a frequently prescribed secretolytic agent which enhances the ciliary beat
frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a …
frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a …
[HTML][HTML] Chloride/Multiple Anion Exchanger SLC26A Family: Systemic Roles of SLC26A4 in Various Organs
Solute carrier family 26 member 4 (SLC26A4) is a member of the SLC26A transporter family
and is expressed in various tissues, including the airway epithelium, kidney, thyroid, and …
and is expressed in various tissues, including the airway epithelium, kidney, thyroid, and …
Putting Bicarbonate on the spot. Implication for theratyping in Cystic Fibrosis
M Zajac, A Lepissier, E Dreano, B Chevalier, A Hatton… - medRxiv, 2023 - medrxiv.org
Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. CFTR controls chloride (Cl-) and bicarbonate (HCO3-) transport …
Regulator (CFTR) protein. CFTR controls chloride (Cl-) and bicarbonate (HCO3-) transport …
Ambroxol-enhanced frequency and amplitude of beating cilia mediated by pHi and [Cl-] i in lung airway epithelial cells of mice
T Nakahari, C Suzuki, K Kawaguchi, S Hosogi… - 2023 - researchsquare.com
Ambroxol (ABX), a frequently prescribed secretolytic agent that stimulates Ca 2+ release
from acidic stores and Ca 2+ entry through Ca V 1.2, enhanced the ciliary beat frequency …
from acidic stores and Ca 2+ entry through Ca V 1.2, enhanced the ciliary beat frequency …
A decrease in ciliary motility induced by a CO2/HCO3--free solution characteristic of ciliated human nasal epithelial cells: acceleration of HCO3-transport by carbonic …
S Okamoto, M Yasuda, K Kawaguchi, K Yasuoka… - 2024 - preprints.org
An application of CO2/HCO3--free solution (Zero-CO2) did not increase intracellular pH
(pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no increase in the …
(pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no increase in the …