Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Long term benefits following short-term administration of high psychedelic doses of
serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine …

Anxiety disorders (ADs) represent the sixth leading cause of disability worldwide, resulting in
a significant global economic burden. Over 50% of individuals with ADs do not respond to …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

In patients affected by Parkinson's disease (PD), up to 50% of them experience cognitive
changes, and psychiatric disturbances, such as anxiety and depression, often precede the …

In the early 1980's, the dispute on the existence of a multiplicity of receptors for
neurotransmitter was at its height. Several subtypes of serotonin (5-HT) receptors were …

Studies on serotonin-selective reuptake inhibitors have established that disturbances in the
ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to …