PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
[HTML][HTML] The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance
PP Ruvolo - BBA clinical, 2016 - Elsevier
Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …
malignant one and can impart survival properties that render cancer cells resistant to …
Combining anti-miR-155 with chemotherapy for the treatment of lung cancers
K Van Roosbroeck, F Fanini, T Setoyama, C Ivan… - Clinical Cancer …, 2017 - AACR
Purpose: The oncogenic miR-155 is upregulated in many human cancers, and its
expression is increased in more aggressive and therapy-resistant tumors, but the molecular …
expression is increased in more aggressive and therapy-resistant tumors, but the molecular …
The role of protein kinase R in the interferon response
A Pindel, A Sadler - Journal of interferon & cytokine research, 2011 - liebertpub.com
The effects of interferons (IFNs) are mediated through the induction of around 2,000 IFN-
stimulated gene (ISG) products. However, the majority of these ISGs do not directly instigate …
stimulated gene (ISG) products. However, the majority of these ISGs do not directly instigate …
miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
U Baumgartner, F Berger, A Hashemi Gheinani… - Molecular cancer, 2018 - Springer
Background Epidermal growth factor receptor (EGFR) mutations enable constitutive active
downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote …
downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote …
Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
B Meeusen, V Janssens - The international journal of biochemistry & cell …, 2018 - Elsevier
Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …
The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells
V Janssens, A Rebollo - Current molecular medicine, 2012 - ingentaconnect.com
A block in apoptotic cell death is a likely requirement for cancer maintenance. Likewise, drug
resistance, one of the key clinical problems in oncology, can often be explained by apoptotic …
resistance, one of the key clinical problems in oncology, can often be explained by apoptotic …
Regulation and role of the PP2A-B56 holoenzyme family in cancer
I Peris, S Romero-Murillo, C Vicente, G Narla… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract Protein phosphatase 2A (PP2A) inactivation is common in cancer, leading to
sustained activation of pro-survival and growth-promoting pathways. PP2A consists of a …
sustained activation of pro-survival and growth-promoting pathways. PP2A consists of a …
Protein phosphatase 2A as a therapeutic target in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic
progenitor cells in which several genetic and epigenetic aberrations have been described …
progenitor cells in which several genetic and epigenetic aberrations have been described …
Regulation of nuclear–cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt
Recent genome-wide association studies reveal that the FAM13A gene is associated with
human lung function and a variety of lung diseases, including chronic obstructive pulmonary …
human lung function and a variety of lung diseases, including chronic obstructive pulmonary …