The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can
potentially be accomplished using the processes of dedifferentiation, transdifferentiation or …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Of all types of DNA damage, DNA double-strand breaks (DSBs) pose the greatest challenge
to cells. One might have, therefore, anticipated that a sizable number of DNA DSBs would be …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phoshoprotein which shuttles
continuously between the nucleus and cytoplasm. Many findings have revealed a complex …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …

An outstanding biological question is why tissue regeneration in mammals is limited,
whereas urodele amphibians and teleost fish regenerate major structures, largely by cell …

During evolution, cells have developed a wide spectrum of stress response modules to
ensure homeostasis. The genome and proteome damage response pathways constitute the …

Background The INK4/ARF locus encodes three tumor suppressor genes (p15Ink4b, Arf and
p16Ink4a) and is frequently inactivated in a large number of human cancers. Mechanisms …