Central nervous system (CNS) metastases are a common complication in patients with
epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer (NSCLC) …

Epidermal growth factor receptor (EGFR), a cancer-driven gene, plays an important role in
tumorigenesis of lung cancer. Cryptotanshinone (CT) is the main constituent of salia …

Activating mutation in exons 19 or 21 of epidermal growth factor receptor (EGFR) in non-
small-cell lung cancers (NSCLC) are associated with increased sensitivity to EGFR tyrosine …

Background Patient-reported symptom and health-related quality of life (HRQoL) benefit of
afatinib, a novel, irreversible, ErbB Family Blocker, was investigated in a double-blind …

Appropriate evidence-based roles of prognostic and predictive biomarkers of known
therapeutic targets in breast, colorectal, and non-small cell lung cancers in adults are …

The discovery that mutations in the EGFR gene are present in up to 50% of patients with
lung adenocarcinoma, and the development of highly efficacious EGFR tyrosine kinase …

Purpose of research Revision of the literature on targeted therapy-induced diarrhea (TT-ID).
Principal results TT-ID is frequent; the mechanisms are mainly secretive, followed by …

Tyrosine kinase inhibitors (TKIs) against human epidermal growth factor receptor
(EGFR/HER) family have been introduced into the clinic to treat cancers, particularly non …

Since the International Association for the Study of Lung Cancer (IASLC), American Thoracic
Society (ATS) and European Respiratory Society (ERS) reported a new lung …

The molecular pathways which promote lung cancer cell features have been broadly
explored, leading to significant improvement in prognostic and diagnostic strategies …