Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

Abstract Type 2 diabetes (T2D) is associated with numerous complications, including
increased risk of fragility fractures, despite seemingly protective factors [eg, normal bone …

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …

The development of osteoporosis is often accompanied by autophagy disturbance, which
also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs) …

Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …

The bony skeleton, as a structural foundation for the human body, is essential in providing
mechanical function and movement. The human skeleton is a highly specialized and …

Abstract Mammalian sirtuins (SIRT1–7) are members of the nicotine adenine dinucleotide
(NAD+)-dependent family of enzymes critical for histone deacetylation and posttranslational …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

Background It remains unknown why adiponectin levels are associated with poor physical
functioning, skeletal muscle mass and increased mortality in older populations. Methods In …

Development of in vivo techniques for intracortical vessel visualization and characterization
will enable the exploration of interactions between the vascular and skeletal systems, and …