Toxoplasma gondii‐induced neuronal alterations

A Parlog, D Schlüter, IR Dunay - Parasite immunology, 2015 - Wiley Online Library
The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The
intracellular parasite can persist lifelong in the CNS within neurons modifying their function …

[HTML][HTML] Neurogliaform and ivy cells: a major family of nNOS expressing GABAergic neurons

C Armstrong, E Krook-Magnuson… - Frontiers in neural circuits, 2012 - frontiersin.org
Neurogliaform and Ivy cells are members of an abundant family of neuronal nitric oxide
synthase (nNOS) expressing GABAergic interneurons found in diverse brain regions. These …

Resveratrol mitigates the oxidative stress mediated by hypoxic-ischemic brain injury in neonatal rats via Nrf2/HO-1 pathway

Y Gao, R Fu, J Wang, X Yang, L Wen… - Pharmaceutical …, 2018 - Taylor & Francis
Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate.
Resveratrol possesses numerous biological properties including antioxidant, anti …

G-CSF attenuates neuroinflammation and stabilizes the blood–brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats

L Li, DW McBride, D Doycheva, BJ Dixon, PR Krafft… - Experimental …, 2015 - Elsevier
Objective Neonatal hypoxia occurs in approximately 60% of premature births and is
associated with a multitude of neurological disorders. While various treatments have been …

HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron …

WD Marks, JJ Paris, CJ Schier, MD Denton… - Journal of …, 2016 - Springer
Memory deficits are characteristic of HIV-associated neurocognitive disorders (HAND) and
co-occur with hippocampal pathology. The HIV-1 transactivator of transcription (Tat), a …

Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers

EJ Fernandez‐Perez, B Muñoz, DA Bascuñan… - Aging cell, 2021 - Wiley Online Library
Intracellular amyloid beta oligomer (iAβo) accumulation and neuronal hyperexcitability are
two crucial events at early stages of Alzheimer's disease (AD). However, to date, no …

Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses

B Dejanovic, G Schwarz - Journal of Neuroscience, 2014 - Soc Neuroscience
Gephyrin, the principal scaffolding protein at inhibitory synapses, is essential for
postsynaptic clustering of glycine and GABA type A receptors (GABAARs). Gephyrin cluster …

G-CSF ameliorates neuronal apoptosis through GSK-3β inhibition in neonatal hypoxia–ischemia in rats

L Li, D Klebe, D Doycheva, DW McBride, PR Krafft… - Experimental …, 2015 - Elsevier
Granulocyte-colony stimulating factor (G-CSF), a growth factor, has known neuroprotective
effects in a variety of experimental brain injury models. Herein we show that G-CSF …

NO-sGC-cGMP signaling influence the anxiolytic like effect of lithium in mice in light and dark box and elevated plus maze

V Walia, C Garg, M Garg - Brain Research, 2019 - Elsevier
Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric
disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase …

N-Acetylaspartylglutamate (NAAG) Pretreatment Reduces Hypoxic-Ischemic Brain Damage and Oxidative Stress in Neonatal Rats

E Bratek, A Ziembowicz, E Salinska - Antioxidants, 2020 - mdpi.com
N-acetylaspartylglutamate (NAAG), the most abundant peptide transmitter in the mammalian
nervous system, activates mGluR3 at presynaptic sites, inhibiting the release of glutamate …