Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

The cytoplasm of animal cells is structured by a scaffolding composed of actin
microfilaments, microtubules, and intermediate filaments. Intermediate filaments, so named …

Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial
tissues in a site-specific and differentiation-dependent manner. The complex network of …

The overall objective of this guideline is to provide the user with information on the
laboratory diagnosis of inherited epidermolysis bullosa (EB) to improve outcomes (Table 1) …

▪ Abstract Many metazoan cells inhabit mechanically stressful environments and,
consequently, their plasma membranes are frequently disrupted. Survival requires that the …

Injury to stratified epithelia causes a strong induction of keratins 6 (K6) and 16 (K16) in post-
mitotic keratinocytes located at the wound edge. We show that induction of K6 and K16 …

Epithelial tissues function to protect the organism from physical, chemical, and microbial
damage and are essential for survival. To perform this role, epithelial keratinocytes undergo …

Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …

It is generally assumed that the vimentin intermediate filament network present in most
mesenchymallyderived cells is in part responsible for the strength and integrity of these …

Keratins are the major structural proteins of the vertebrate epidermis and its appendages,
constituting up to 85% of a fully differentiated keratinocyte. Together with actin …