COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases

S Valdebenito, S Bessis, D Annane… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …

Nitric oxide in the pathogenesis and treatment of tuberculosis

H Jamaati, E Mortaz, Z Pajouhi, G Folkerts… - Frontiers in …, 2017 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally
known as one of the most important human pathogens. Mtb is estimated to infect nearly one …

Host defense mechanisms against Mycobacterium tuberculosis

Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …

Neutrophils in tuberculosis: Cell biology, cellular networking and multitasking in host defense

RR Borkute, S Woelke, G Pei, A Dorhoi - International journal of molecular …, 2021 - mdpi.com
Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In
tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis …

Tuberculosis vaccine development: progress in clinical evaluation

SB Sable, JE Posey, TJ Scriba - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …

Type I interferons in the pathogenesis of tuberculosis: molecular drivers and immunological consequences

ML Donovan, TE Schultz, TJ Duke… - Frontiers in …, 2017 - frontiersin.org
Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB
include improved and innovative treatment options for drug-sensitive and-resistant TB as …

Interaction of mycobacteria with host cell inflammasomes

S Rastogi, V Briken - Frontiers in Immunology, 2022 - frontiersin.org
The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

MK Bisht, P Dahiya, S Ghosh… - Frontiers in cellular and …, 2023 - frontiersin.org
Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of
mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal …

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

J Sousa, B Cá, AR Maceiras, L Simões-Costa… - Nature …, 2020 - nature.com
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical
outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune …

Plasma proinflammatory cytokines are markers of disease severity and bacterial burden in pulmonary tuberculosis

NP Kumar, K Moideen, VV Banurekha… - Open forum …, 2019 - academic.oup.com
Abstract Background Type 1, type 17, and other proinflammatory cytokines are important in
host immunity to tuberculosis (TB) in animal models. However, their role in human immunity …