Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Background Systemic sclerosis (SSc) is an autoimmune disease characterized by
overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed …

ABSTRACT Introduction Systemic sclerosis (SSc) is a severe, and often life-threatening,
autoimmune disease, which causes inflammation and fibrosis of the skin and internal …

Systemic sclerosis (SSc) is a progressive, multiorgan disease with limited treatment options.
Although a recent proof-of-concept study using romilkimab or SAR156597, a bispecific IL …

Objective We undertook this study to investigate the effect of B cell depletion on fibrosis in
systemic sclerosis (SSc) and its mechanism of action. Methods Mice with bleomycin …

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and
excessive fibrosis of the skin and internal organs. To this day, no effective treatments to …

Semaphorin (Sema) 4A is a transmembrane glycoprotein that is elevated in several
autoimmune diseases such as systemic sclerosis, rheumatoid arthritis and multiple …

The interrelations and sequencing of interleukins are complex (inter) actions where each
interleukin can stimulate the secretion of its preceding interleukin. In this paper, we attempt …