Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …

The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin,
is incompletely understood. Here we demonstrate, using a combination of single cell and …

Background Systemic sclerosis (SSc) is an autoimmune disease characterized by
overproduction of extracellular matrix (ECM) and multiorgan fibrosis. Animal studies pointed …

Systemic sclerosis (SSc) is a progressive, multiorgan disease with limited treatment options.
Although a recent proof-of-concept study using romilkimab or SAR156597, a bispecific IL …

Objective We undertook this study to investigate the effect of B cell depletion on fibrosis in
systemic sclerosis (SSc) and its mechanism of action. Methods Mice with bleomycin …

Objectives Prior work demonstrates that co-cultured macrophages and fibroblasts from
patients with SSc engage in reciprocal activation. However, the mechanism by which these …

Abstract Background Systemic sclerosis (SSc) is a multiorgan autoimmune disease
characterized by inflammation, vascular modification, and progressive fibrosis of the skin …

Bullous pemphigoid, mucous membrane pemphigoid, and pemphigus vulgaris are different
cutaneous autoimmune blistering diseases, with complex pathogenic mechanisms. In all of …

Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and
homeostasis by modulating how the immune system is activated. Several studies have …