The win ratio was introduced in 2012 as a new method for examining composite endpoints
and has since been widely adopted in cardiovascular (CV) trials. Improving upon …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of
hospitalization for heart failure and cardiovascular death among patients with chronic heart …

Background In patients with type 2 diabetes, inhibitors of sodium–glucose cotransporter 2
(SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose …

Background The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with
acute ischemic stroke but who have no evidence of complete occlusion of large or medium …

Importance Additional treatments are needed for heart failure with reduced ejection fraction
(HFrEF). Sodium-glucose cotransporter 2 (SGLT2) inhibitors may be an effective treatment …

The win ratio is a general method of comparing locations of distributions of two independent,
ordinal random variables, and it can be estimated without distributional assumptions. In this …

The win ratio, a recently proposed measure for comparing the benefit of two treatment
groups, allows ties in the data but ignores ties in the inference. In this article, we highlight …

Background The Mobile Health (mHealth) Technology for Improved Screening and
Optimized Integrated Care in atrial fibrillation (AF)(mAFA-II) cluster randomized trial …

Conventional analyses of a composite of multiple time‐to‐event outcomes use the time to
the first event. However, the first event may not be the most important outcome. To address …

Abstract The National Research Council's report on the prevention and treatment of missing
data highlighted the need to clearly specify causal estimands. This focus fundamentally …