[HTML][HTML] A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
Deterioration of lung function during the first week of COVID-19 has been observed when
patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) …
patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) …
3D printed deformable sensors
The ability to directly print compliant biomedical devices on live human organs could benefit
patient monitoring and wound treatment, which requires the 3D printer to adapt to the …
patient monitoring and wound treatment, which requires the 3D printer to adapt to the …
[HTML][HTML] COVID-19 ARDS: points to be considered in mechanical ventilation and weaning
The COVID-19 disease can cause hypoxemic respiratory failure due to ARDS, requiring
invasive mechanical ventilation. Although early studies reported that COVID-19-associated …
invasive mechanical ventilation. Although early studies reported that COVID-19-associated …
Multiscale modeling of lung mechanics: from alveolar microstructure to pulmonary function
DE Hurtado, N Avilés-Rojas, F Concha - … of the Mechanics and Physics of …, 2023 - Elsevier
The mechanical behavior of the lungs has long been associated with the structural
properties of alveoli in pulmonary medicine. However, this structure-function relationship …
properties of alveoli in pulmonary medicine. However, this structure-function relationship …
[HTML][HTML] Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation
DE Hurtado, B Erranz, F Lillo, M Sarabia-Vallejos… - Annals of intensive …, 2020 - Springer
Background Protective mechanical ventilation (MV) aims at limiting global lung deformation
and has been associated with better clinical outcomes in acute respiratory distress …
and has been associated with better clinical outcomes in acute respiratory distress …
[HTML][HTML] Mechanics of pulmonary airways: linking structure to function through constitutive modeling, biochemistry, and histology
Breathing involves fluid-solid interactions in the lung; however, the lack of experimental data
inhibits combining the mechanics of air flow to airway deformation, challenging the …
inhibits combining the mechanics of air flow to airway deformation, challenging the …
[HTML][HTML] Prediction of treatment response to neoadjuvant chemotherapy for breast cancer via early changes in tumor heterogeneity captured by DCE-MRI registration
We analyzed DCE-MR images from 132 women with locally advanced breast cancer from
the I-SPY1 trial to evaluate changes of intra-tumor heterogeneity for augmenting early …
the I-SPY1 trial to evaluate changes of intra-tumor heterogeneity for augmenting early …
[HTML][HTML] Diseased and healthy murine local lung strains evaluated using digital image correlation
TM Nelson, KAM Quiros, EC Dominguez, A Ulu… - Scientific reports, 2023 - nature.com
Tissue remodeling in pulmonary disease irreversibly alters lung functionality and impacts
quality of life. Mechanical ventilation is amongst the few pulmonary interventions to aid …
quality of life. Mechanical ventilation is amongst the few pulmonary interventions to aid …
Mechanical and morphological characterization of the emphysematous lung tissue
Irreversible alveolar airspace enlargement is the main characteristic of pulmonary
emphysema, which has been extensively studied using animal models. While the alterations …
emphysema, which has been extensively studied using animal models. While the alterations …
[HTML][HTML] Whole-lung finite-element models for mechanical ventilation and respiratory research applications
N Avilés-Rojas, DE Hurtado - Frontiers in Physiology, 2022 - frontiersin.org
Mechanical ventilation has been a vital treatment for Covid-19 patients with respiratory
failure. Lungs assisted with mechanical ventilators present a wide variability in their …
failure. Lungs assisted with mechanical ventilators present a wide variability in their …