Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Communication problems (eg, dysphonia, dysfluency and language and articulation
disorders), swallowing disorders (dysphagia and globus), cough and upper airway …

Background Risk factors for chronic cough in the general population have not been
described systematically. We identified and ranked chronic cough risk factors at the …

Introduction To determine the optimal dose of sivopixant, a highly selective P2X3 receptor
antagonist, for refractory or unexplained chronic cough (RCC/UCC). Methods In this phase …

P2X receptors are cation channels that sense extracellular ATP. Many therapeutic
candidates targeting P2X receptors have begun clinical trials or acquired approval for the …

ABSTRACT Introduction: Chronic Cough (CC) is common and often associated with
significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is …

Functional brain imaging in individuals with chronic cough demonstrates reduced activation
in cortical regions associated with voluntary cough suppression. Little is known about the …

Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are common
problems seen in primary care and subspecialty clinics. The role of cough hypersensitivity …

Background Refractory chronic cough (RCC) has a significant impact on patient's health-
related quality of life and represents a challenge in clinical management. However, the …

Background The differential sensitivity of cough to antitussive therapies implies the
existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is …