A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Caffeine (1, 3, 7-trimethylxanthine) is the most consumed psychoactive substance in the
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …

Cadmium (Cd) is a toxic pollutant with high nephrotoxicity in the agricultural environment.
Resveratrol has been found to have a renoprotective effect but the underlying mechanisms …

Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50
years ago and which possess high complexity and display a broad field of activity. They are …

This leading textbook in the field examines the mechanisms underlying toxicity, particularly
the events at the molecular level and the factors that determine and affect toxicity. The new …

Abstract The cytochrome P450 (P450) enzymes are the major catalysts involved in the
metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

Various aspects of the reactivity of iron (IV) in chemical and biological systems are reviewed.
Accumulated evidence shows that the ferryl species [Fe (IV) O] 2+ can be formed under a …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

▪ Abstract Plant secondary metabolites (PSMs) significantly impact the nutritional ecology of
terrestrial vertebrate herbivores. Herbivores have a wide range of mechanisms (herbivore …