Targeting aldehyde dehydrogenase 2: new therapeutic opportunities
CH Chen, JCB Ferreira, ER Gross… - Physiological …, 2014 - journals.physiology.org
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …
Caffeine consumption through coffee: Content in the beverage, metabolism, health benefits and risks
J dePaula, A Farah - Beverages, 2019 - mdpi.com
Caffeine (1, 3, 7-trimethylxanthine) is the most consumed psychoactive substance in the
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …
Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated …
Q Zhang, C Zhang, J Ge, MW Lv, M Talukder, K Guo… - Food & function, 2020 - pubs.rsc.org
Cadmium (Cd) is a toxic pollutant with high nephrotoxicity in the agricultural environment.
Resveratrol has been found to have a renoprotective effect but the underlying mechanisms …
Resveratrol has been found to have a renoprotective effect but the underlying mechanisms …
Cytochromes P450 as versatile biocatalysts
R Bernhardt - Journal of biotechnology, 2006 - Elsevier
Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50
years ago and which possess high complexity and display a broad field of activity. They are …
years ago and which possess high complexity and display a broad field of activity. They are …
[图书][B] Principles of biochemical toxicology
JA Timbrell - 2008 - taylorfrancis.com
This leading textbook in the field examines the mechanisms underlying toxicity, particularly
the events at the molecular level and the factors that determine and affect toxicity. The new …
the events at the molecular level and the factors that determine and affect toxicity. The new …
Cytochrome P450s and other enzymes in drug metabolism and toxicity
FP Guengerich - The AAPS journal, 2006 - Springer
Abstract The cytochrome P450 (P450) enzymes are the major catalysts involved in the
metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug …
metabolism of drugs. bioavailability and toxicity are 2 of the most common barriers in drug …
[HTML][HTML] Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners
M Šrejber, V Navrátilová, M Paloncýová… - Journal of inorganic …, 2018 - Elsevier
Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
High-valent iron in chemical and biological oxidations
JT Groves - Journal of inorganic biochemistry, 2006 - Elsevier
Various aspects of the reactivity of iron (IV) in chemical and biological systems are reviewed.
Accumulated evidence shows that the ferryl species [Fe (IV) O] 2+ can be formed under a …
Accumulated evidence shows that the ferryl species [Fe (IV) O] 2+ can be formed under a …
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
high social cost. Depressed patients generally display co-morbid symptoms, and depression …
The influence of plant secondary metabolites on the nutritional ecology of herbivorous terrestrial vertebrates
MD Dearing, WJ Foley, S McLean - Annu. Rev. Ecol. Evol. Syst., 2005 - annualreviews.org
▪ Abstract Plant secondary metabolites (PSMs) significantly impact the nutritional ecology of
terrestrial vertebrate herbivores. Herbivores have a wide range of mechanisms (herbivore …
terrestrial vertebrate herbivores. Herbivores have a wide range of mechanisms (herbivore …