Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

Visualizing synaptic connectivity has traditionally relied on time-consuming electron
microscopy-based imaging approaches. To scale the analysis of synaptic connectivity …

Mechanosensation is essential for normal gastrointestinal (GI) function, and abnormalities in
mechanosensation are associated with GI disorders. There are several mechanosensitive …

Bacteria in the gut microbiome play an intrinsic part in immune activation, intestinal
permeability, enteric reflex, and entero-endocrine signaling. The gut microbiota …

Somatostatin, a somatotropin release inhibiting factor (SST, SRIF), is a widely distributed
multifunctional cyclic peptide and acts through a transmembrane G protein-coupled receptor …

The enteric nervous system (ENS) is the intrinsic nervous system that innervates the entire
digestive tract and regulates major digestive functions. Recent evidence has shown that …

Somatostatin (SST)/somatotropin release-inhibiting factor (SRIF) is a well-known
neuropeptide, widely distributed in the central and peripheral nervous systems, that …

Background Ex vivo intracellular recordings and dye fills, combined with
immunohistochemistry, are a powerful way to analyze the enteric nervous system of …

GI toxicity is a common dose-limiting adverse effect of platin chemotherapy treatment. Up to
50% of cancer survivors continue to experience symptoms of chronic constipation or …