Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …

The development and clinical application of inhibitors that target the epidermal growth factor
receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the …

The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

Purpose This phase I clinical trial is designed to assess the safety and feasibility of the
epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) T-cell generated …

EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …

Background: The most accurate predictor of disease recurrence in patients treated for head
and neck squamous cell carcinoma is, at present, the extent of regional lymph node …

The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell
differentiation and proliferation upon activation through the binding of one of its ligands. The …

In 135 primary breast cancers, there was a significant inverse relation between epidermal-
growth-factor receptor (EGFR) and oestrogen receptor (ER) status, and a significant …