Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …

Intervertebral disc degeneration is a very common type of degenerative disease causing
severe socioeconomic impact, as well as a major cause of discogenic low back pain and …

Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and
radicular pain. IVD degeneration is characterized by increases in levels of the …

Although mesenchymal stem cells (MSC s) transplantation into the IVD (intervertebral disc)
may be beneficial in inhibiting apoptosis of nucleus pulposus cells (NPC s) and alleviating …

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

Objectives Circular RNAs (circRNAs) have been proven to function as competing
endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of …

The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This
study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD …

Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …