Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

In the last few decades, targeting cancer by the use of dietary phytochemicals has gained
enormous attention. The plausible reason and believe or mind set behind this fact is …

Autophagy is a conserved biological phenomenon that maintains cellular homeostasis
through the clearing of damaged cellular components under cellular stress and offers the …

Silibinin is a natural plant polyphenol with high antioxidant and anticancer properties, which
causes broad-spectrum efficacy against cancer, including cell cycle arrest and apoptosis in …

Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating
resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a …

Chestnut kernels are often used for direct consumption; or processed to produce marron
glacé, chestnut purée, and gluten‐free products, while chestnut by‐products (inner shell and …

Cell death is closely related to autophagy under some circumstances; however, the effect of
isoorientin (ISO) on autophagy and the interplay between apoptosis and autophagy in …

The nuclear transcription factor p53, discovered in 1979, has a broad range of biological
functions, primarily the regulation of apoptosis, the cell cycle, and DNA repair. In addition to …

Silibinin, also known as silybin, is the major flavonolignan isolated from Silybum marianum.
Although previous reports demonstrated that silibinin exhibits significant tumor suppressor …

Anticancer activity of silibinin, a flavonoid, has been demonstrated in various cancer cell
types. However, the underlying mechanisms were not elucidated in human ovarian cancer …