Bidirectional effects of pyrrolidine dithiocarbamate on severe acute pancreatitis in a rat model
H Yang, SC Ma, Y Guo, DL Cui, JF Yao - Dose-Response, 2019 - journals.sagepub.com
Introduction: The mechanism by which intestinal mucosal barrier is damaged in severe
acute pancreatitis (SAP)-associated impairment is not fully understood. Methods: We …
acute pancreatitis (SAP)-associated impairment is not fully understood. Methods: We …
Interruption of mitochondrial complex IV activity and cytochrome c expression activated O2∙−-mediated cell survival in silibinin-treated human melanoma A375-S2 …
Y Jiang, H Huang, H Wang, D Wu, R Yang… - European journal of …, 2011 - Elsevier
Silibinin was reported to have high cyto-toxicity in many malignant cell lines, however, it
showed low cyto-toxicity in treatment of human melanoma A375-S2 cells and even protected …
showed low cyto-toxicity in treatment of human melanoma A375-S2 cells and even protected …
The cytogenetic effects of silibinin alone and in combination with methotrexate in mouse bone marrow
HG Oufi - European journal of pharmacology, 2018 - Elsevier
The use of herbal drugs for disease treatment has increased worldwide. Flavonolignan
silibinin, the major biologically active component of milk thistle (Silybum marianum), has …
silibinin, the major biologically active component of milk thistle (Silybum marianum), has …
Parthenolide complements the cell death-inducing activity of doxorubicin in melanoma cells
M Wozniak, A Szulawska-Mroczek… - Anticancer …, 2013 - ar.iiarjournals.org
Background: Melanoma is characterized by high resistance to chemotherapy. The aim of this
study was to investigate combined effects of doxorubicin and parthenolide on melanoma …
study was to investigate combined effects of doxorubicin and parthenolide on melanoma …
Silibinin induced apoptosis of human epidermal cancer A431 cells by promoting mitochondrial NOS
Y Yu, L Li, J Tao, X Zhou, C Xu - Free radical research, 2019 - Taylor & Francis
The antitumor effects of silibinin are of increasing interest, though its mechanism is not yet
clear. The goal of this study was to clarify the mechanism of silibinin-induced cell death in …
clear. The goal of this study was to clarify the mechanism of silibinin-induced cell death in …
Silibinin negatively contributes to primary cilia length via autophagy regulated by histone deacetylase 6 in confluent mouse embryo fibroblast 3T3-L1 cells
Q Xu, W Liu, X Liu, W Liu, H Wang, G Yao… - Molecular and Cellular …, 2016 - Springer
Primary cilium is a cellular antenna, signalling as a sensory organelle. Numerous
pathological manifestation is associated with change of its length. Although the interaction …
pathological manifestation is associated with change of its length. Although the interaction …
Evaluation of anti-cancer potency of silibinin on murine renal carcinoma RenCa cells in an animal model with an intact immune system
C Yang, F Li, J Ma, HB Zhang, J Jia, J Zeng… - Anti-Cancer …, 2020 - journals.lww.com
Silibinin is a flavonoid extract isolated from milk thistle and has been proved to be a
promising chemotherapeutic drug for cancer. However, most of those studies were …
promising chemotherapeutic drug for cancer. However, most of those studies were …
[PDF][PDF] Targeting Drug Chemo-Resistance in Cancer Using Natural Products. Biomedicines 2021, 9, 1353
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …