Acute myeloid leukemia (AML) arises from the cells of myeloid lineage and is the most
frequent leukemia type in adulthood accounting for about 80% of all cases. The most …

The study of marrow-resident mesodermal progenitors can provide important insight into
their role in influencing normal and aberrant hematopoiesis as occurs in acute myelogenous …

Simple Summary Reduced response to glucocorticoids (GCs, such as dexamethasone,
Dex), first-line drugs employed during therapy induction, is considered a poor prognosis …

Background The tumor microenvironment (TME) is a supportive environment responsible for
promoting the growth and proliferation of tumor cells. Current studies have revealed that the …

Acute lymphoblastic leukemia with the worst prognosis is related to minimal residual
disease. Minimal residual disease not only depends on the individual peculiarities of …

Background Immunological phenotypes and differentiation statuses commonly decide the T
cell function and anti-tumor ability. However, little is known about these alterations in CML …

Mesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic
fibroblast-like cells which play important roles in tissue repair, inflammation, and immune …

Abstract Chronic Myeloid Leukemia (CML) is characterized by chromosomal aberrations
involving the fusion of the BCR and ABL genes on chromosome 22, resulting from a …

B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) blasts strictly depend on the
transport of extra‐cellular asparagine (Asn), yielding a rationale for L‐asparaginase …

Presence of minimal residual disease (MRD), detected by flow cytometry, is an important
prognostic biomarker in the management of B‐cell precursor acute lymphoblastic leukemia …