The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Regulated cell death (RCD) refers to programmed cell death regulated by various protein
molecules, such as apoptosis, autophagy‐dependent cell death, and necroptosis …

Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth,
development, survival, and metabolism through integration of diverse extracellular and …

Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which
functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 …

Type 2 diabetes mellitus (T2DM) is an epidemiological risk factor for dementia and has been
implicated in multifactorial pathologies, including neuroinflammation. In the present study …

There is a pressing need for innovative therapeutic strategies for patients with epithelial
ovarian cancer (EOC). Previous studies have shown that UNC-51-like kinase 1 (ULK1), a …

Esophageal cancer (EC) is the sixth most common and the seventh most deadly malignancy
of the digestive tract, representing a major global health challenge. Despite the availability of …

Autophagy is a highly conserved cellular degradation process that regulates cellular
metabolism and homeostasis under normal and pathophysiological conditions. Autophagy …

Goats contribute significantly to the global food security and industry. They constitute a main
supplier of meat and milk for large proportions of people in Egypt and worldwide. Brucellosis …

Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer
relapse and metastasis, thereby leading to an increase in the overall survival rate. However …