Flavones: Six selected flavones and their related signaling pathways that induce apoptosis in cancer

SH Jeong, HH Kim, SE Ha, MY Park… - International Journal of …, 2022 - mdpi.com
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

M Shi, Z Chen, H Gong, Z Peng, Q Sun… - Phytotherapy …, 2024 - Wiley Online Library
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …

Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis

X Liu, X Peng, S Cen, C Yang, Z Ma… - Frontiers in Pharmacology, 2023 - frontiersin.org
Pancreatic cancer is a common gastrointestinal tract malignancy. Currently, the therapeutic
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy

T Wu, Z Zhang, G Gong, Z Du, Y Xu, S Yu, F Ma… - European Journal of …, 2023 - Elsevier
CDK9 plays a vital role in regulating RNA transcription and significantly impacts the
expression of short-lived proteins such as Mcl-1 and c-Myc. Thus, targeting CDK9 holds …

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

J Cai, Q Hu, Z He, X Chen, J Wang, X Yin, X Ma, J Zeng - Molecules, 2023 - mdpi.com
Ovarian cancer (OC) is one of the most common types of cancer in women with a high
mortality rate, and the treatment of OC is prone to high recurrence rates and side effects …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

The role of gut microbial β-glucuronidase in drug disposition and development

S Gao, R Sun, R Singh, SY So, CTY Chan… - Drug discovery today, 2022 - Elsevier
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …

RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development

Y Bai, Y Qiao, M Li, W Yang, H Chen, Y Wu… - European Journal of …, 2024 - Elsevier
Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

J Wang, S Chen, J Zhang, J Wu - Frontiers in pharmacology, 2022 - frontiersin.org
Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes
self-tolerance failure, and the common members of which include multiple sclerosis …

Wogonin, as a potent anticancer compound: From chemistry to cellular interactions

HS Tuli, P Rath, A Chauhan… - Experimental …, 2023 - journals.sagepub.com
Chinese native medicine Scutellaria baicalensis Georgi, also referred to as Chinese
skullcap or Huang-Qin, is frequently used to treat cancer, viral infections, and seizures. This …