Flavones: Six selected flavones and their related signaling pathways that induce apoptosis in cancer
SH Jeong, HH Kim, SE Ha, MY Park… - International Journal of …, 2022 - mdpi.com
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …
Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches
M Shi, Z Chen, H Gong, Z Peng, Q Sun… - Phytotherapy …, 2024 - Wiley Online Library
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis
X Liu, X Peng, S Cen, C Yang, Z Ma… - Frontiers in Pharmacology, 2023 - frontiersin.org
Pancreatic cancer is a common gastrointestinal tract malignancy. Currently, the therapeutic
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy
T Wu, Z Zhang, G Gong, Z Du, Y Xu, S Yu, F Ma… - European Journal of …, 2023 - Elsevier
CDK9 plays a vital role in regulating RNA transcription and significantly impacts the
expression of short-lived proteins such as Mcl-1 and c-Myc. Thus, targeting CDK9 holds …
expression of short-lived proteins such as Mcl-1 and c-Myc. Thus, targeting CDK9 holds …
Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review
J Cai, Q Hu, Z He, X Chen, J Wang, X Yin, X Ma, J Zeng - Molecules, 2023 - mdpi.com
Ovarian cancer (OC) is one of the most common types of cancer in women with a high
mortality rate, and the treatment of OC is prone to high recurrence rates and side effects …
mortality rate, and the treatment of OC is prone to high recurrence rates and side effects …
Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …
The role of gut microbial β-glucuronidase in drug disposition and development
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …
RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development
Y Bai, Y Qiao, M Li, W Yang, H Chen, Y Wu… - European Journal of …, 2024 - Elsevier
Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …
pathways in the hopes of discovering new drugs. Over the past two decades …
Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases
J Wang, S Chen, J Zhang, J Wu - Frontiers in pharmacology, 2022 - frontiersin.org
Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes
self-tolerance failure, and the common members of which include multiple sclerosis …
self-tolerance failure, and the common members of which include multiple sclerosis …
Wogonin, as a potent anticancer compound: From chemistry to cellular interactions
Chinese native medicine Scutellaria baicalensis Georgi, also referred to as Chinese
skullcap or Huang-Qin, is frequently used to treat cancer, viral infections, and seizures. This …
skullcap or Huang-Qin, is frequently used to treat cancer, viral infections, and seizures. This …