Natural killer cells: from innate to adaptive features

AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

[HTML][HTML] IL-1 family members in cancer; two sides to every story

KJ Baker, A Houston, E Brint - Frontiers in immunology, 2019 - frontiersin.org
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …

[HTML][HTML] iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

[HTML][HTML] Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment

X Wu, H Yang, X Chen, J Gao, Y Duan, D Wei, J Zhang… - Biomaterials, 2021 - Elsevier
A variety of therapies have been developed and used for the treatment of colon cancer,
however, the high mortality rate remains high and more effective strategies are still in urgent …

The IL-1 family in tumorigenesis and antitumor immunity

R Sun, DS Gao, J Shoush, B Lu - Seminars in cancer biology, 2022 - Elsevier
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

[HTML][HTML] NK cell therapy: A rising star in cancer treatment

N Du, F Guo, Y Wang, J Cui - Cancers, 2021 - mdpi.com
Simple Summary A cancer treatment approach known as immunotherapy has become
popular in the medical field. In this case, immune cells are boosted for effective response …

[HTML][HTML] NK-cell-mediated targeting of various solid tumors using a B7-H3 tri-specific killer engager in vitro and in vivo

DA Vallera, S Ferrone, B Kodal, P Hinderlie… - Cancers, 2020 - mdpi.com
Simple Summary B7-H3 costimulatory ligand has sparked tremendous interest as a target
for antibody-directed therapy of solid tumors. This is attributed to high expression of B7-H3 …

[HTML][HTML] Cytokine-induced memory-like NK cells: from the basics to clinical applications

I Terrén, A Orrantia, G Astarloa-Pando… - Frontiers in …, 2022 - frontiersin.org
Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …

[HTML][HTML] Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3

YM Chung, PP Khan, H Wang, WB Tsai… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Stimulating antitumor immunity by blocking programmed death-1 (PD-1) or its
ligand (programmed death-ligand 1 (PD-L1) is a promising antitumor therapy. However …