Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

The functions of, and interactions between, the innate and adaptive immune systems are
vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …

The view of cancer as a tumor cell-centric disease is now replaced by our understanding of
the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts (CAFs) …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

The development of immunotherapeutic monoclonal antibodies targeting checkpoint
inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands, such as PD …

Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …