The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

Tumor immunotherapy is an artificial stimulation of the immune system to enhance anti-
cancer response. It has become a powerful clinical strategy for treating cancer. The number …

Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …

The immune system plays an essential and central role in tumor cell differentiation,
proliferation, angiogenesis, apoptosis, invasion, and metastasis. Over the past decade …

Natural killer (NK) cell-based immunotherapy represents a promising strategy to overcome
the bottlenecks of cancer treatment. However, the therapeutic efficacy is greatly limited by …

Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have
shown promise in reinvigorating antitumor immunity. However, approved small molecule …

Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The
conventional treatment options for cancer have numerous challenges, such as a low blood …

Discovery of effective chemical sensitizers to synergize with natural killer cells
immunotherapy is urgently desired to overcome its unsatisfactory efficacy in clinic. Herein …

Immuno-oncology has revolutionized cancer treatment and has opened up new
opportunities for developing vaccination methods. DNA-based cancer vaccines have …

Despite the clinical success of cancer immunotherapies, the majority of patients fail to
respond or develop resistance through disruption of pathways that promote neo-antigen …