In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …

Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …

Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …

Obesity-related disease complications reduce life quality and expectancy and increase
health-care costs. Some studies have suggested that obesity not always entails metabolic …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …

Background Obesity is associated with an increased risk of insulin resistance and type 2
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Breast cancer progression is highly dependent on the heterotypic interaction between tumor
cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes …

MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene
expression by targeting messenger RNA, inducing translational repression and messenger …

Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …