Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells

KNC Murthy, GK Jayaprakasha, S Safe, BS Patil - Food & Function, 2021 - pubs.rsc.org
In our recent study, we demonstrated that certain limonoids isolated from citrus seeds
induced apoptosis in human pancreatic (Panc-28) cells. In this study, limonin, nomilin and …

An insight into the role of citrus bioactives in modulation of colon cancer

J Kaur, G Kaur - Journal of Functional Foods, 2015 - Elsevier
Citrus fruits are important health promoting fruits rich in a number of bioactive components
mainly flavonoids, limonoids, coumarins, volatile oils and carotenoids. Citrus bioactives …

Characterization of Citrus aurantifolia bioactive compounds and their inhibition of human pancreatic cancer cells through apoptosis

JR Patil, GK Jayaprakasha, KNC Murthy, MB Chetti… - Microchemical …, 2010 - Elsevier
In the current study, we have isolated and purified five putative compounds from lime (Citrus
aurantifolia Swingle) seeds using Soxhlet extraction and chromatographic separation. The …

Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cells

J Kim, GK Jayaprakasha, RM Uckoo, BS Patil - Food and chemical …, 2012 - Elsevier
Extracts from lemon seed were investigated for the radical scavenging activity and apoptotic
effects in human breast adenocarcinoma (MCF-7) cells and non-malignant breast (MCF …

Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling

LG Valerio Jr, KB Arvidson, RF Chanderbhan… - Toxicology and applied …, 2007 - Elsevier
Consistent with the US Food and Drug Administration (FDA) Critical Path Initiative, predictive
toxicology software programs employing quantitative structure–activity relationship (QSAR) …

Food systems approach to cancer prevention

J Vanamala - Critical reviews in food science and nutrition, 2017 - Taylor & Francis
New cancer cases are expected to surge 57% worldwide in the next two decades. The
greatest burden will be in low-and middle-income countries that are ill equipped to face this …

Citrus limonoids and curcumin additively inhibit human colon cancer cells

KNC Murthy, GK Jayaprakasha, BS Patil - Food & function, 2013 - pubs.rsc.org
In the current study, we examined the ability of limonoids, including limonin, limonin
glucoside (LG) and curcumin, to inhibit proliferation of human colon cancer (SW480) cells …

Grapefruit (Citrus paradisi Macfad) Phytochemicals Composition Is Modulated by Household Processing Techniques

RM Uckoo, GK Jayaprakasha… - Journal of food …, 2012 - Wiley Online Library
Grapefruits (Citrus paradisi Macfad) contain several phytochemicals known to have health
maintaining properties. Due to the consumer's interest in obtaining high levels of these …

[HTML][HTML] Identification of characteristic volatile compounds and prediction of fermentation degree of pomelo wine using partial least squares regression

Q Wei, G Liu, C Zhang, J Sun, Y Zhang - Lwt, 2022 - Elsevier
The aim of this study was to evaluate the characteristic volatile organic compounds (VOCs)
profile of pomelo wine and determine an index for predicting fermentation degree of pomelo …

Dietary‐feeding of grape seed extract prevents azoxymethane‐induced colonic aberrant crypt foci formation in fischer 344 rats

B Velmurugan, RP Singh, R Agarwal… - Molecular …, 2010 - Wiley Online Library
Chemoprevention by dietary agents/supplements has emerged as a novel approach to
control various malignancies, including colorectal cancer (CRC). This study assessed …