Big data approaches to decomposing heterogeneity across the autism spectrum

MV Lombardo, MC Lai, S Baron-Cohen - Molecular psychiatry, 2019 - nature.com
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …

From the genetic architecture to synaptic plasticity in autism spectrum disorder

T Bourgeron - Nature Reviews Neuroscience, 2015 - nature.com
Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …

Profound concerns about “profound autism”: Dangers of severity scales and functioning labels for support needs

SK Kapp - Education Sciences, 2023 - mdpi.com
Recently the Lancet published a Commission on the future of care and clinical research of
autism, which included a side panel arguing for the adoption of “profound autism”, a term in …

Autism severity and its relationship to disability

E Waizbard‐Bartov, D Fein, C Lord… - Autism …, 2023 - Wiley Online Library
Autism severity is currently defined and measured based exclusively on the severity levels of
the two core symptom domains: social‐communication and restricted or repetitive patterns of …

Brain connectivity and neuroimaging of social networks in autism

RA Müller, I Fishman - Trends in cognitive sciences, 2018 - cell.com
Impairments in social communication (SC) predominate among the core diagnostic features
of autism spectrum disorders (ASDs). Neuroimaging has revealed numerous findings of …

ASD validity

L Waterhouse, E London, C Gillberg - Review Journal of Autism and …, 2016 - Springer
ASD research is at an important crossroads. The ASD diagnosis is important for assigning a
child to early behavioral intervention and explaining a child's condition. But ASD research …

Autism plus versus autism pure

C Gillberg, E Fernell - Journal of autism and developmental disorders, 2014 - Springer
The reported prevalence of autism is going up and up. We propose that some—even much—
of the increase in the rate of autism spectrum disorder (ASD) is driven by “Autism Plus” …

Idiosyncratic brain activation patterns are associated with poor social comprehension in autism

L Byrge, J Dubois, JM Tyszka, R Adolphs… - Journal of …, 2015 - Soc Neuroscience
Autism spectrum disorder (ASD) features profound social deficits but neuroimaging studies
have failed to find any consistent neural signature. Here we connect these two facts by …

ASD comorbidity in fragile X syndrome: Symptom profile and predictors of symptom severity in adolescent and young adult males

L Abbeduto, AJ Thurman, A McDuffie, J Klusek… - Journal of Autism and …, 2019 - Springer
Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD
symptoms in adolescent and young adult males with FXS (n= 44) and (2) evaluate the …

[HTML][HTML] Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions

JT McCracken, E Anagnostou, C Arango… - European …, 2021 - Elsevier
In 2017, facing lack of progress and failures encountered in targeted drug development for
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …