The RNA polymerase II carboxy-terminal domain (CTD) code
D Eick, M Geyer - Chemical reviews, 2013 - ACS Publications
The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …
nucleic acid-based universal code for the maintenance and inheritance of genetic …
The RNA polymerase II CTD coordinates transcription and RNA processing
The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
Cracking the RNA polymerase II CTD code
S Egloff, S Murphy - Trends in genetics, 2008 - cell.com
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …
Multiple links between transcription and splicing
AR Kornblihtt, M De La Mata, JP Fededa, MJ Munoz… - Rna, 2004 - rnajournal.cshlp.org
Transcription and pre-mRNA splicing are extremely complex multimolecular processes that
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …
A structural perspective of CTD function
A Meinhart, T Kamenski, S Hoeppner… - Genes & …, 2005 - genesdev.cshlp.org
The C-terminal domain (CTD) of RNA polymerase II (Pol II) integrates nuclear events by
binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific …
binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific …
RNA polymerase II C-terminal domain: tethering transcription to transcript and template
JL Corden - Chemical reviews, 2013 - ACS Publications
By definition the CTD consists of the amino acid sequences extending from the largest
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
subunit, RPO21 or RPB1 in yeast and POLR2A in human. Specifically the CTD consists of …
Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition
N Czudnochowski, CA Bösken, M Geyer - Nature communications, 2012 - nature.com
Phosphorylation of RNA polymerase II carboxy-terminal domain (CTD) in hepta-repeats
YSPTSPS regulates eukaryotic transcription. Whereas Ser5 is phosphorylated in the …
YSPTSPS regulates eukaryotic transcription. Whereas Ser5 is phosphorylated in the …
The RNA polymerase II CTD: the increasing complexity of a low-complexity protein domain
The largest subunit of RNA polymerase II contains a C-terminal domain (CTD) that plays key
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20
M de la Mata, AR Kornblihtt - Nature structural & molecular biology, 2006 - nature.com
Previous studies have linked the C-terminal domain (CTD) of RNA polymerase II (pol II) with
cotranscriptional precursor messenger RNA processing, but little is known about the CTD's …
cotranscriptional precursor messenger RNA processing, but little is known about the CTD's …
Threonine‐4 of mammalian RNA polymerase II CTD is targeted by Polo‐like kinase 3 and required for transcriptional elongation
C Hintermair, M Heidemann, F Koch… - The EMBO …, 2012 - embopress.org
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the
consensus sequence Tyr1‐Ser2‐Pro3‐Thr4‐Ser5‐Pro6‐Ser7 at the carboxy‐terminal …
consensus sequence Tyr1‐Ser2‐Pro3‐Thr4‐Ser5‐Pro6‐Ser7 at the carboxy‐terminal …