This bachelor's thesis deals with the genetics of coronary artery disease. Studying risk
variants helps us identify risk patients and allows us to develop targeted medicine. The first …

Coronary artery disease is the most common form of heart disease resulting primarily from
atherosclerosis 125, 126. The cellular and molecular mechanisms underlying …

High radiation doses (> 5 Gy) are known to increase the risk of CVD [41]. In recent years,
epidemiological data support the fact that lower radiation doses could increase the risk of …

My lab is interested in developing non-infectious HIV virus-like particles (VLPs) as candidate
HIV mucosal vaccines for both preventive and therapeutic purposes. In preclinical studies …

Background Mice with a single copy of Mclk1 (aka Coq7), a gene that encodes a
mitochondrial enzyme required for the biosynthesis of ubiquinone and other functions, live …

Key Points Estrogen loss during and after menopause increases the risk of developing
several diseases. This chapter describes the available animal models for studying the …

The formation of atherosclerotic plaques is linked to a change in vascular function, with
evidence of endothelial dysfunction and the proliferation of the underlying vascular smooth …

Nos últimos anos, evidências epidemiológicas, clínicas e experimentais indicam a
associação entre a hipercolesterolemia e prejuízos cognitivos, como a demência associada …

Aos colegas da Petrobrás, pelo apoio. A todos os meus amigos, pela torcida. A minha
família (Mamãe, Dri e Philipe), pelo incentivo, paciência e compreensão nos momentos de …

Chemokine-induced macrophage recruitment into the vascular wall is an early pathological
event in the progression of atherosclerosis. Macrophage activation and chemotaxis during …