[HTML][HTML] The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma
Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …
Supramolecular cancer nanotheranostics
Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …
Carbohydrate-based macromolecular biomaterials
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
[HTML][HTML] Safe nanoparticles: are we there yet?
W Najahi-Missaoui, RD Arnold… - International journal of …, 2020 - mdpi.com
The field of nanotechnology has grown over the last two decades and made the transition
from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles …
from the benchtop to applied technologies. Nanoscale-sized particles, or nanoparticles …
An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain
P Wang, L Yu, J Gong, J Xiong, S Zi… - Angewandte Chemie …, 2022 - Wiley Online Library
Peroxynitrite (ONOO−) plays a critical role in Alzheimer's disease (AD). To reveal the
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …
ONOO− influx in AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was …
[HTML][HTML] Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma
G Lu, X Wang, F Li, S Wang, J Zhao, J Wang… - Nature …, 2022 - nature.com
Glioblastoma multiforme (GBM) is an aggressive brain cancer with a poor prognosis and few
treatment options. Here, building on the observation of elevated lactate (LA) in resected …
treatment options. Here, building on the observation of elevated lactate (LA) in resected …
[HTML][HTML] A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma
H Chen, T Li, Z Liu, S Tang, J Tong, Y Tao… - Nature …, 2023 - nature.com
The major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor
sites accurately and properly activate complex immune responses. Herein, we design and …
sites accurately and properly activate complex immune responses. Herein, we design and …
[HTML][HTML] Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy
R Sun, M Liu, J Lu, B Chu, Y Yang, B Song… - Nature …, 2022 - nature.com
Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …