The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

Currently, there are several studies supporting the role of urokinase‐type plasminogen
activator (uPA) system in cancer. The association of uPA to its receptor triggers the …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

Elevated level of urokinase receptor (uPAR) is detected in various aggressive cancer types
and is closely associated with poor prognosis of cancers. Binding of uPA to uPAR triggers …

Proteolysis is a key event in several biological processes; proteolysis must be tightly
controlled because its improper activation leads to dramatic consequences. Deregulation of …

Simple Summary The uPA/uPAR system is highly involved in cancer progression and
metastasis. Many studies have definitively assessed that the high expression of urokinase …

The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell
membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. Its …